MSU unraveled the mechanism of packaging the DNA molecule

Researchers Laboratory MSU became the authors of a scientific sensation. They were able to see how the DNA strand length of two meters is placed in a core diameter of not more than one hundredth of a millimeter. Further analysis will reveal this discovery methods of treating many serious diseases, including cancer.

In the laboratory, MSU made a discovery, which now says the scientific world. Russian scientists have been able to understand the mechanisms inside the cell genome packaging.

It is still not clear why cells, such as skin or retina, differ from each other, although all contain the same genome. It turns out that this may depend on how the carrier of genetic information - DNA molecule - is laid in the space.

“DNA that encodes all of our genes is very long - the length of about two meters, and the size of the nucleus, where it is located, is about 10 microns. Accordingly, it should be very compactly stacked to just fit into this kernel. But the problem - much more complicated, because it should not just there to be laid, and be laid so that those parts of it that now, at the current moment, demand, or in the cells claimed to have been available to those machines that, say, read the information from the DNA “- says Head of the Department of Molecular Biology, Moscow State University Sergey Razin.

For a long DNA molecule is not confused, it is screwed to the particular structure of the protein in the form of kegs. But the genome - is not strong ball of yarn. At a certain section of DNA, it turns out, is wound tightly on the other - no. Researchers believe that the packing density is directly related to the work of genes.

“In this project we will for the first time in our laboratory and, as far as I know, the first time in Russia used a method that allows you to map the three-dimensional organization of the whole genome. When genes are working hard, then this site is straightened, if these genes are silent in another cell line, This site is “to collapse” into a denser configuration “- said a senior researcher at the Department of Molecular Biology, Moscow State University Sergey Ulyanov.

Stick together and razlipayutsya sections of DNA under the influence of specific enzymes where it is needed at the moment for the construction of new cells. Validate the findings helped the biological process modeling on a supercomputer “Lomonosov”. During his second each processor performs thousands of millions of transactions. To calculate the model of DNA, it took 200 of these processors, and three days ………

5 December 2015

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